In-vitro test for developmental neurotoxicity
2021
University of Veterinary Medicine Hannover, Hannover, Germany
In this study, the pesticide fipronil and its main metabolic product, fipronil sulfone, as well as the known developmental neurotoxicant rotenone were tested on the human neuronal precursor cell line NT2.
The assay tested three developmental neurotoxicity (DNT) endpoints: neurite outgrowth, neuronal differentiation, and precursor cell migration in a dose-dependent manner.
Fipronil and fipronil sulfone were shown to inhibit cell migration and neuronal differentiation and displayed specific developmental neurotoxicity on developing human model neurons.
Developmental neurotoxicity of fipronil and rotenone on a human neuronal in vitro test system
Michael Stern
Added on: 08-08-2022
[1] https://link.springer.com/article/10.1007/s12640-021-00364-8
