Non Animal Testing Database

In-vitro test for developmental neurotoxicity

University of Veterinary Medicine Hannover, Hannover, Germany
In this study, the pesticide fipronil and its main metabolic product, fipronil sulfone, as well as the known developmental neurotoxicant rotenone were tested on the human neuronal precursor cell line NT2. The assay tested three developmental neurotoxicity (DNT) endpoints: neurite outgrowth, neuronal differentiation, and precursor cell migration in a dose-dependent manner. Fipronil and fipronil sulfone were shown to inhibit cell migration and neuronal differentiation and displayed specific developmental neurotoxicity on developing human model neurons.
Developmental neurotoxicity of fipronil and rotenone on a human neuronal in vitro test system
Michael Stern
Added on: 08-08-2022
Back to Top
English German

Warning: Internet Explorer

The IE from MS no longer understands current scripting languages, the latest main version (version 11) is from 2013 and has not been further developed since 2015.

Our recommendation: Use only the latest versions of modern browsers, for example Google Chrome, Mozilla Firefox or Microsofrt Edge, because only this guarantees you sufficient protection against infections and the correct display of websites!