Non Animal Testing Database

Microfluidic thyroid-liver model

Bayer SAS, Lyon, France
Human three-dimensional thyroid and liver organoids with key functions of thyroid hormone metabolism are presented. The thyroid model resembled in-vivo-like follicular architecture and the liver model, secreting critical thyroid hormone-binding proteins, emulated an active thyroid hormone catabolism. The established single-tissue models were successfully co-cultured in a perfused two-organ chip for 21 days. In conclusion, this model presents a first step towards a complex multimodular human platform reflecting the liver-thyroid axis, which will help to identify both direct and indirect thyroid disruptors that are relevant from a human safety perspective.
A microfluidic thyroid-liver platform to assess chemical safety in humans
Julia Kühnlenz
Added on: 05-31-2022
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