Flower lose, a cell fitness marker, predicts COVID-19 prognosis
October 2021
Champalimaud Centre for the Unknown, Lisbon, Portugal(1)
University Hospital Basel and University of Basel, Basel, Switzerland(2)
University Hospital Basel and University of Basel, Basel, Switzerland(2)
A post-mortem examination of COVID-19 infected human lung tissues and an observational study were performed in order to evaluate whether expression of cell fitness marker hFwe-Lose in patient's nasopharyngeal swabs could predict hospitalization or death from COVID-19. In COVID-19 patients with acute lung injury, hFwe-Lose was highly expressed in the lower respiratory tract and was co-localised with areas of cell death. The hFwe-Lose expression in the patient's nasal swabs accurately predicted subsequent hospitalization or death due to COVID-19 infection. hFwe-Lose outperformed conventional inflammatory biomarkers and patient age and comorbidities in predicting hospitalization/death due to COVID-19 infection.
Flower lose, a cell fitness marker, predicts COVID-19 prognosis
Rajan Gogna(1), Eduardo Moreno(1), Alexandar Tzankov(2)
Added on: 05-12-2022
[1] https://www.embopress.org/doi/full/10.15252/emmm.202013714[2] https://www.bionity.com/en/news/1173302/biomarker-predicts-severity-of-covid-19-infection-early-on.html
