One important question is whether the pathological α-synuclein (αSynP) detected by immunohistochemistry in the skin of individuals with Parkinson's disease (PD) has aggregation seeding activity, and is skin αSynP seeding activity a potential biomarker for diagnosis of PD and other synucleinopathies. In this diagnostic study including skin samples from 160 autopsies and 41 biopsies, a statistically significant increase in αSynP seeding activity was observed in individuals with PD and synucleinopathies compared with controls with tauopathies and non-neurodegenerative diseases. This study provides a proof-of-concept that skin αSynP seeding activity may serve as a novel biomarker for antemortem diagnoses of PD and other synucleinopathies.
Skin α-synuclein aggregation seeding activity as a novel biomarker for Parkinson disease
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