Non Animal Testing Database

Ultra-sensitive cancer detector from 2D materials

October 2021
Singapore University of Technology and Design, Singapore, Singapore
Changes in lipid composition and structure during cell development can be markers for cell apoptosis or various diseases such as cancer. However, current methods are limited in studying these micro-changes as they require complex probe preparation and cannot be reused, making cell monitoring and detection challenging. Here, the researchers developed a direct current (DC) resistance sensor based on two-dimensional (2D) molybdenum disulfide nanosheets to enable cancer cell-specific detection dependent on micro-changes in the cancer cell membrane. The analysis revealed that previously unconsidered perturbations in the lipid bilayer can cause an increase in resistance. Furthermore, a correlation was observed between the resistance and breast cancer epithelial cell (MCF-7) population, illustrating a cell population-dependent sensitivity of the method. The method has a detection limit that is below the baseline for the current state-of-the-art electrical-based biosensors. This combination of a unique 2D material and electrical resistance framework represents a promising approach for the early detection of cancerous cells and to reduce the risk of post-surgery cancer recurrence.
Ultrasensitive two-dimensional material-based MCF-7 cancer cell sensor driven by perturbation processes
Desmond K. Loke, Natasa Bajalovic
Added on: 05-12-2022
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