Changes in lipid composition and structure during cell development can be markers for cell apoptosis or various diseases such as cancer. However, current methods are limited in studying these micro-changes as they require complex probe preparation and cannot be reused, making cell monitoring and detection challenging. Here, the researchers developed a direct current (DC) resistance sensor based on two-dimensional (2D) molybdenum disulfide nanosheets to enable cancer cell-specific detection dependent on micro-changes in the cancer cell membrane. The analysis revealed that previously unconsidered perturbations in the lipid bilayer can cause an increase in resistance. Furthermore, a correlation was observed between the resistance and breast cancer epithelial cell (MCF-7) population, illustrating a cell population-dependent sensitivity of the method. The method has a detection limit that is below the baseline for the current state-of-the-art electrical-based biosensors. This combination of a unique 2D material and electrical resistance framework represents a promising approach for the early detection of cancerous cells and to reduce the risk of post-surgery cancer recurrence.
Ultrasensitive two-dimensional material-based MCF-7 cancer cell sensor driven by perturbation processes
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