Organ-on-a-chip model of bone marrow
2022
University of California, Davis, USA
In this study, a novel microfluidic device is presented that is capable of supporting two separate niches of human bone marrow while maintaining physiological proximity and communication. The microtissue model of human bone marrow displayed a perfusable, 3D vascular network and expression of extracellular matrix proteins and other biomarkers that are present in the native bone marrow. Hematopoietic stem/progenitor cells were cultured and maintained in the device for up to two weeks and were able to differentiate into mature neutrophils that could egress from the marrow compartment and into adjacent microfluidic lines. The platform allows for investigation of the stem cell niche and was used to visualize cancer metastasis; thus, it may also be a useful tool for drug discovery or investigation of haematological diseases.
Organ-on-a-chip model of vascularized human bone marrow niches
Steven C. George
Added on: 04-28-2022
[1] https://www.sciencedirect.com/science/article/abs/pii/S0142961221006025
