3D bioprinting of bone marrow structure for hematopoietic and cancer models
2021
Rutgers New Jersey Medical School, Newark, USA
In this study, methylcellulose-alginate hydrogel bioinks were fabricated and the bioink composition was optimized to mimic the gross architecture, availability of oxygen, and rheological characteristics of bone marrow. The material was tested using human mesenchymal stem cells and endothelial cells from healthy human donors as well as human breast cancer cells.
The resulting scaffolds were suitable for long-term cultures and offer a foundation for modification with bioactive factors and tissue-specific components to further enhance bone marrow mimicry. Furthermore, it was shown that the structure could be applied to study breast cancer behaviour in bone marrow. Thus, the material can serve as a model to study the healthy microenvironment of the bone marrow, and to uncover new methods to target elusive cancer cells.
A 3D bioprinted material that recapitulates the perivascular bone marrow structure for sustained hematopoietic and cancer models
Pranela Rameshwar
Added on: 04-28-2022
[1] https://www.mdpi.com/2073-4360/13/4/480
