A transcriptome-wide association study of tissue-dependent gene expression
2020
University of Bristol, Bristol, United Kingdom
Applying an approach called Mendelian randomization, researchers integrated the genomic dataset from the Genotype-Tissue Expression (GTEx) project, which contains transcription information for over 32,000 genes based on a range of 80 to 491 samples from 48 different human tissues, with the results from 395 genome-wide association studies. This integration constructed a genome-wide atlas of tissue-dependent regulatory mechanisms, providing increased understanding of the determinants of complex diseases.
A transcriptome-wide mendelian randomization study to uncover tissue-dependent regulatory mechanisms across the human phenome
Tom G. Richardson
Tom G. Richardson et al. Nature Communications 2020 [1]
Physicians Committee for Responsible Medicine [2]
Added on: 05-26-2020
[1] https://www.nature.com/articles/s41467-019-13921-9#Sec8
[2] https://www.pcrm.org/news/ethical-science/analyzing-regulatory-mechanisms-gene-expression-across-human-tissue-types?fbclid=IwAR0HTVJP0tRCZ7bOE7qwr8m4RW_qlZyOOvesoxEWv4TIU3q6_SoH5EjZfv4
