Patient study to investigate the relationship between heart rate variability and severity of COPD
2022
University of California Los Angeles, Los Angeles, USA
The aim of this study was to investigate the relationships between heart rate variability (HRV) and various phenotypic measures related to health and functional status in chronic obstructive pulmonary disease (COPD), and secondly, to demonstrate the feasibility of determining HRV via a chest-worn biosensor in COPD patients. In 79 patients with COPD, the associations between HRV and COPD severity, prescribed bronchodilator therapy, and patient-reported outcomes were examined. This study confirmed that HRV is reduced in mild to very severe COPD and that HRV correlates with several measures of health status and exercise capacity but is not affected by disease severity progression. The data suggest that the effects of inhaled bronchodilators on the autonomic nervous system most likely contribute to reduced HRV in COPD. In addition, the results suggest that determination of HRV by means of a chest-worn biosensor in COPD patients and thus continuous monitoring of physiological parameters (HRV, physical activity) may be significant to assess the functional status of patients, detect abnormal parameters early, and take appropriate action.
Use of a wearable biosensor to study heart rate variability in chronic obstructive pulmonary disease and its relationship to disease severity
Christopher B. Cooper
Added on: 03-30-2022
[1] https://www.mdpi.com/1424-8220/22/6/2264/htm
