3D printed cancer metastasis model
2022
Wuhan University, Wuhan, China(1)
Zhongnan Hospital of Wuhan University, Wuhan, China(2)
Zhongnan Hospital of Wuhan University, Wuhan, China(2)
To develop a 3D model for cancer invasion, an acoustic bioprinting technology was used to construct tumour microtissues. Cancer-associated fibroblasts (CAFs) derived from a colorectal cancer patient were incorporated into gel droplets and printed into a 3D microtissue. After depositing a tumour organoid derived from the same patient, the 3D bio-printed microtissue was used to model the cancer cell migration and invasion from the tumour organoid into the 3D CAF microtissue. The drug sensitivity of the invasion model was tested using the clinical drug 5-Fluorouracil (5-FU). The invasion phenomenon and drug treatment results were highly consistent with clinical diagnosis and treatment. By using patient-derived cancer samples, the assay holds potential for personalized treatment.
Model cancer metastasis using acoustically bio-printed patient-derived 3D tumor microtissues
Shishang Guo(1), Hang Hu(2)
Added on: 03-17-2022
[1] https://pubs.rsc.org/en/content/articlelanding/2022/tb/d1tb02789a
