Tonsil organoids elucidate adaptive immune responses
2021
Stanford University, Stanford, USA
Currently, most of the studies on adaptive immunity have been done on mouse models with limited translationality. Moreover, vaccine assays in mice are usually poorly predictive of their outcome in humans. Here, human tonsils are used to develop physiological and functionally relevant organotypic cultures that recapitulate in vitro key germinal characteristics to perform immunity assays. The results elucidated the critical cellular components to induce an immune response to an influenza vaccine. Furthermore, it was also possible to trigger humoral immunity when testing vaccines against SARS-CoV-2 or rabies and using different adjuvants. Overall, the researchers develop an in vitro system that allows to rapidly test vaccines and adjuvants in a human system and evaluate the adaptive immune response and the mechanisms underlying it.
Modeling human adaptive immune responses with tonsil organoids
Mark M Davis
Added on: 12-02-2021
[1] https://www.nature.com/articles/s41591-020-01145-0
