Subtypes of degenerative mitral valve disease distinguished by microRNAs profiling
2016
National University of Singapore, Singapore, Singapore
In developed countries, degenerative mitral valve disease (DMVD) is the leading indication for mitral valve surgery. Two variants can be distinguished: myxomatous mitral valve prolapse (MMVP) and fibroelastic deficiency (FED). In the present study, the researchers aimed at understanding the molecular mechanisms differentiating these two types. As a model, the researchers used valvular specimens from MMVP and FED patients obtained from a tissue bank. Total RNA was extracted from the tissues and micro RNA were sequenced. A cluster of differentially expressed microRNAs was identified. In silico analysis of potential target sites for regulation by these microRNAs revealed genes involved in extracellular matrix homeostasis. The study showed microRNAs which could be used as diagnostic biomarkers and targets for therapeutics development.
Differential microRNA expression profile in myxomatous mitral valve prolapse and fibroelastic deficiency valves
Yei-Tsung Chen
Added on: 11-30-2021
[1] https://www.mdpi.com/1422-0067/17/5/753[2] https://data.jrc.ec.europa.eu/dataset/20947a04-86ef-473f-8907-c658e4050c24
