Sensitive and specific multi-cancer detection test
2020
US Oncology Research, The Woodlands, USA
Targeted methylation analysis of cell-free DNA (cfDNA) in 6689 cancer patients and healthy volunteers simultaneously detected and localized >50 cancer types, including high-mortality cancers that lack screening paradigms. Cancers were detected across all stages at a specificity of >99%. This targeted methylation approach localized the tissue of origin with >90% accuracy. The goal of this test is to enable early multi-cancer detection.
Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA
Michael V. Seiden
Added on: 05-25-2020
[1] https://www.annalsofoncology.org/article/S0923-7534(20)36058-0/fulltext
