Available treatments for the influenza A virus are scarce and every year there are fatal cases. Moreover, current models have severe limitations and this hinders the development of new therapies. In recent years, bioprinting techniques have evolved into efficient tools to reproduce human microtissue environments to study infectious pathogenic mechanisms. Here, human primary lung fibroblasts, human monocytic cells and human alveolar epithelial cells were printed with a hydrogel-based bioink to build a human lung model to investigate pathological mechanisms of infectious diseases. The results showed that this model supported long-term culture. Moreover, challenge with bacterial toxins and ATP induced an immune response through the secretion of inflammatory cytokines. Furthermore, virus replication after infection of the model could be inhibited with an antiviral agent in a dose-dependent manner. Overall, the researchers develop a 3D human lung model that replicates the alveolar microenvironment and is suitable to investigate pathological mechanisms in lung diseases, including infectious diseases, and explore new therapeutical strategies.
Bioprinted multi-cell type lung model for the study of viral inhibitors
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