Disrupted crosstalk between endothelial cells and pericytes or vascular smooth muscle cells leads to several vascular diseases. Currently, there are some human models that can recapitulate part of the pathological mechanisms, however, there are still critical limitations. Here, human induced pluripotent stem cells are used to develop a multicellular 3D vessel-on-a-chip to model vascular networks. The results showed that the cells were able to self-organise mimicking physiologically functional in vivo structures. Moreover, it was possible to quantify phenotypical and functional parameters in an automated manner. Overall, the researchers propose a reproducible human-based 3D model of microvasculature that replicates in vivo characteristics and could be potentially applied to study vascular physiology and disease mechanisms to develop therapeutical strategies.
Engineered 3D vessel-on-chip using hiPSC-derived endothelial- and vascular smooth muscle cells
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