In silico correction of an arrhythmia model based on human induced pluripotent stem cells
2013
University at Buffalo, Buffalo, USA
Despite the potential of cardiac myocytes derived from induced pluripotent stem cells (iPSCs), problems with this system have been noted, leading to serious concerns about their use in studying arrhythmogenic mechanisms and drug safety screening. Action potentials (APs) from hiPSC-derived cardiocytes are often referred to as an “immature phenotype". In the present study, the researchers aimed at complementing the use of iPSCs with an in silico approach to rectify the immature phenotype. Electrophysiology was performed on iPSCs derived cardiomyocytes treated with different drugs in vitro, the data was then processed using an in silico platform to turn the immature electric activity into a mature one and obtain expected phenotypes. The study concludes that this in silico platform is the appropriate complement of hiPSC-derived cardiac myocytes to be used for arrhythmia modelling.
Electronic "expression" of the inward rectifier in cardiocytes derived from human-induced pluripotent stem cells
Randall L Rasmusson, Glenna C L Bett
Added on: 11-29-2021
[1] https://linkinghub.elsevier.com/retrieve/pii/S1547-5271(13)01071-0[2] https://data.jrc.ec.europa.eu/dataset/20947a04-86ef-473f-8907-c658e4050c24
