Lung-on-a-chip to perform drug screening
2018
Shanghai University, Shanghai, China
Organ-on-a-chip models are gaining interest to perform drug testing, due to their capacities in replicating in vitro pathophysiological features of different organs. Here, a custom organ-on-a-chip scaffold was built with biofabrication techniques and cultured with human non-small cell lung cancer cells and human fetal lung fibroblasts to model the alveolar microenvironment and evaluate gefitinib as an anti-tumor drug. The results showed that there is a potential interplay between both cell types driving cell resistance of cancer cells. Moreover, when they were co-cultured with human umbilical endothelial cells, cancer cells led to a decrease in endothelial cell viability and triggered metastatic behaviour. Overall, the researchers propose an easy-to-adjust lung-on-a-chip model with the potential to be used in personalized medicine and high-throughput drug screening.
Nanofiber membrane supported lung-on-a-chip microdevice for anti-cancer drug testing
Xinghua Gao
Added on: 11-28-2021
[1] https://pubs.rsc.org/en/content/articlelanding/2018/LC/C7LC01224A[2] https://data.jrc.ec.europa.eu/dataset/176d71e6-5082-4b29-8472-b719f6bda323
