3D microfluidic model for anti-metastatic drug screening
October 2015
Massachusetts Institute of Technology, Cambridge, USA
In this study, a microfluidic device recapitulating tumor microenvironment was developed by co-culturing cancer cell aggregates in 3D scaffolds with human umbilical vein endothelial cells to perform drug screening of epithelial-to-mesenchymal inhibitors against metastatic processes. The results showed that the presence of endothelial cells in different compartments induced cell dispersal of lung adenocarcinoma cells, which could be inhibited with all drugs tested. Contrary, none of the inhibitors could completely block bladder carcinoma cells dissemination, but the use of all the drugs combined almost could. However, this effect was inhibited with direct co-culture with human endothelial cells through growth factors signalling. Overall, the researchers provide a new 3D microfluidic platform that simulates in vivo microenvironments to perform drug screening and design effective therapeutical strategies.
Identification of drugs as single agents or in combination to prevent carcinoma dissemination in a microfluidic 3D environment
Roger D Kamm
Added on: 11-27-2021
[1] https://www.oncotarget.com/article/5464/[2] https://data.jrc.ec.europa.eu/dataset/176d71e6-5082-4b29-8472-b719f6bda323
