Semi-open breathing alveolar lung-on-a-chip
Company 2018
AleveoliX, Bern, Switzerland
Primary human pulmonary alveolar cells (hAEpCs) and primary pulmonary endothelial cells are cultivated in the system. They are applied to both sides of a thin, flexible membrane to create a bioartificial, flexible alveolar barrier. A cyclical negative pressure is generated in the cavity located below the micro-membrane. This simulated breathing is important because it influences the permeability of the epithelial barrier. It offers easy sampling and high throughput and is also compatible with a number of standard readout techniques including ELISA, transepithelial electrical resistance (TEER), permeability testing, qPCR, immune staining and electron microscopy. It is ideal for general lung research, basic research on pulmonary alveoli, preclinical testing of new drugs and can ultimately enable patient-specific precision medicine.
Medium throughput breathing human primary cell alveolus-on-chip model
www.alveolix.com
Added on: 05-25-2020
[1] https://www.nature.com/articles/s41598-018-32523-x[2] https://www.alveolix.com/our-products/#page-top
