Human midbrain organoids
2017
University of Luxembourg, Esch-sur-Alzette, Luxembourg
The authors developed a robust human brain organoid system that is highly specific to the midbrain derived from regionally patterned neuroepithelial stem cells. Spatially organized groups of dopaminergic neurons, make this model suitable for Parkinson’s disease modelling and therapy development. The midbrain organoids are characterized in for neuronal, astroglial, and oligodendrocyte differentiation, the presence of synaptic connections, electrophysiological activity, and myelination of neurites.
Derivation of human midbrain-specific organoids from neuroepithelial stem cells.
Jens C. Schwamborn
Added on: 05-25-2020
[1] https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(17)30116-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2213671117301169%3Fshowall%3Dtrue
