Functional human midbrain-like organoids
2016
Genome Institute of Singapore, Singapore, Singapore
The authors developed 3D multilayer midbrain organoids with functionally mature and electrically active dopaminergic neurons from human iPSCs. Importantly, unlike 2D cell cultures, the human midbrain organoids produce neuromelanin-like granules that were structurally similar to those isolated from human substantia nigra tissues and are implicated in Parkinson’s disease.
Midbrain-like organoids from human pluripotent stem cells contain functional dopaminergic and neuromelanin-producing neurons.
Huck-Hui Ng
Added on: 05-25-2020
[1] https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(16)30200-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1934590916302004%3Fshowall%3Dtrue
