Human 3D respiratory models
CompanyEpithelix, Geneva, Switzerland
MUCILAIR and MUCILAIR-HF from Epithelix are reconstructed complex 3D models of the human pulmonary epithelium and of nasal, bronchial and tracheal tissue. These are highly differentiated, metabolically and functionally active multicellular systems with mobile cilia and mucus production. They are generated from human primary cells obtained during surgery. In MUCILAIR-HF, these are still co-cultured with human airway fibroblasts. Different models are available: healthy epithelium, cigarette smoke, COPD, asthma, allergic rhinitis, cystic fibrosis (different gene variants); all reconstructed from primary cells of patients, phenotype preserved in culture. Also, a lung cancer model is available (lung epithelial cells, fibroblasts and adenocarcinoma cells), which remains functional over several months. In general, the models can be cultivated for more than 1 year (air-liquid interface). The cultures are delivered as ready-to-use cell culture plates, suitable for rapid assays and high throughput analyses with spectrophotometric detection.
www.epithelix.com
Added on: 05-25-2020
[1] https://www.epithelix.com/products/mucilair-smallair-hf[2] https://www.epithelix.com/products/mucilair
