Breast cancer metastasis suppressor 1 inhibits cell invasion in breast cancer cells
October 2015
Konyang University, Daejeon, South Korea
Epithelial-to-mesenchymal transition is a critical step in cancer metastasis. Breast cancer metastasis suppressor 1 has been identified as a metastasis suppressor, but the underlying mechanisms that attenuate cancer cell metastatic transformation remain unknown. Here, human breast cancer cell lines were used to investigate the molecular interactions that drive the suppression of cancer cell metastatic behaviour induced by Breast cancer metastasis suppressor 1 activity. The results showed that Breast cancer metastasis suppressor 1 strongly inhibited TGF-beta1 induced epithelial-to-mesenchymal transition and cell invasion. Moreover, other cell invasion-related genes were downregulated by Breast cancer metastasis suppressor 1 as a consequence of the reduced TGF-beta1 induced expression of a transcription regulator. Finally, the signalling mechanism by which Breast cancer metastasis suppressor 1 affects transcriptional activity was elucidated. Overall, the researchers describe the signalling cascade by which Breast cancer metastasis suppressor 1 inhibits cancer cell invasion features in breast cancer cells.
Breast cancer metastasis suppressor 1 (BRMS1) attenuates TGF-β1-induced breast cancer cell aggressiveness through downregulating HIF-1α expression
Hoi Young Lee
Added on: 10-30-2021
[1] https://bmccancer.biomedcentral.com/articles/10.1186/s12885-015-1864-y[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
