Interactions between blood vessel and spinal neuronal tissues on-a-chip
Company 2018
Cedars-Sinai Medical Center, Los Angeles, USA(1)
Emulate Inc., Boston, USA(2)
Emulate Inc., Boston, USA(2)
The researchers used an organ-on-a-chip model to study the interaction between human blood vessel tissue and spinal cord tissue derived from human stem cells (iPSCs). They discovered that the blood vessel tissue can activate genes to direct the development and maturation of spinal cord tissue. The study not only offers insights into how spinal cord tissues develop, it also offers an experimental model to study diseases affected by defects in motion-controlling brain cells, such as amyotrophic lateral sclerosis (ALS).
Human iPSC-derived endothelial cells and microengineered Organ-Chip enhance neuronal development
Clive N. Svendsen(1), Samuel Sances(1), (2)
Added on: 05-25-2020
[1] https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(18)30103-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2213671118301036%3Fshowall%3Dtrue
