Study of serotonin effect on immune regulation using cells from multiple sclerosis patients
2018
Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil
MS is a chronic and debilitating condition affecting the CNS due to an immune attack against the myelin sheath. Serotonin is a CNS neurotransmitter that plays an important role in the regulation of many physiological processes and has been found to modulate the functional profile of certain immune cells. In the present study, the researchers aimed at evaluating the ability of exogenous serotonin to modulate the T-cell behaviour of patients with MS. Serotonin could attenuate in vitro the T-cell proliferation and cytokines production using cells isolated from patients. Also, serotonin favoured the expansion of regulatory T cells (Tregs) which suppress the immune response. The effect of serotonin in upregulating Treg cells was inversely correlated with the number of active brain lesions. To conclude, the data suggest that serotonin may play a protective role in the pathogenesis of MS.
Serotonin decreases the production of Th1/Th17 cytokines and elevates the frequency of regulatory CD4+ T-cell subsets in multiple sclerosis patients
Cleonice A. M. Bento
Added on: 10-29-2021
[1] https://onlinelibrary.wiley.com/doi/10.1002/eji.201847525[2] https://data.jrc.ec.europa.eu/dataset/700397b2-edd7-4ed6-86f7-fc1b164ed432
