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iPSC-based model for Parkinson pathogenesis

2018
Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
#axonal transport, #iPSCs, #neurodegeneration, #neurons, #Parkinson, #synucleinopathies
The authors employ human induced pluripotent stem cells (iPSCs) from Parkinson patients to elucidate the role of a-Synuclein (a-Syn) in neurodegeneration. The study shows that a-syn oligomers cause synaptic degeneration and neuron toxicity, and thus may represent a putative therapeutic target.
α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies
Iryna Prots

Iryna Prots et al. PNAS 2018 [1]   URL
Friedrich-Alexander-Universität Erlangen-Nürnberg [2]   URL
#106
Added on: 05-25-2020
[1] https://www.pnas.org/content/115/30/7813.long [2] https://www.fau.de/2018/07/news/wissenschaft/gestoerte-transportwege-in-nervenzellen-als-eine-ursache-von-parkinson/
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