miRNAs as biomarkers of breast cancer
2016
Georgetown University Medical Center, Washington, USA
In recent years, microRNAs have been described as potential solid biomarkers for breast cancer detection and evaluation. However, there is still high variability among different studies, which leads to difficulties in the interpretation of the data. Other sources than blood have the potential to be used for biomarker detection and solve some of its limitations, like ductal lavage and nipple aspirate fluids. Here, fluid from the ductal lavage of breast cancer patients was used to perform a miRNA transcriptomic analysis. The results identified 17 differentially expressed miRNAs in breast tumors related to several processes of breast cancer development and metastasis. These miRNAs were not limited to this fluid, but could also be detected in samples of other origins. Several signalling pathways involved in breast cancer were elucidated through the analysis of the candidate miRNAs. Additionally, it was described that the miRNA expression profile was specific to different histological types of the tumors. Overall, the researchers demonstrate that the analysis of miRNAs in the ductal fluid can be a potential tool to be used as biomarkers of breast cancer with non-invasive procedures.
MicroRNA analysis of breast ductal fluid in breast cancer patients
Bassem R Haddad
Added on: 10-25-2021
[1] https://www.spandidos-publications.com/ijo/48/5/2071[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
