MMP-8 is essential for tumor suppressor function of myoepithelial cells
2017
Queen Mary University of London, London, United Kingdom
Under normal conditions, myoepithelial cells have a tumor-suppressor role in the breast. However, in ductal carcinoma in situ, they gain a tumor-promoter behaviour. One of the changes described in these transformed cells is the loss of expression of MMP-8. Here, MMP-8 expression was modulated in normal and ductal carcinoma in situ associated myoepithelial cells to investigate how it affects cancer-related features. The results confirmed a loss of expression of MMP-8 in cancer-related cells. Across all the assays performed in this study, the overexpression of MMP-8 could reduce cancer-related features, while the knock-down of MMP-8 induced cancer cell characteristics, with special emphasis on processes related to cell migration and invasion. Finally, the expression of MMP-8 correlated negatively with the presence of invasion in ductal carcinoma in situ samples from patients. Overall, the researchers confirm that MMP-8 is essential for the tumor-suppressor function of myoepithelial cells and its loss is related to increased metastatic behaviour, making it a potential biomarker for the risk assessment of ductal carcinoma in situ progression.
Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function
J Louise Jones, Michael D Allen
Added on: 10-21-2021
[1] https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-017-0822-9[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
