Patients' immune cells used to understand the involvement of receptors in multiple sclerosis
2017
Lausanne University Hospital, Epalinges, Switzerland
Multiple sclerosis (MS) is a frequent chronic inflammatory disease of the central nervous system leading to neurologic disability and lifelong morbidity in young adults. Immune cell migration is a key point in the disease process. In the present study, the researchers aimed at discovering the potential role of chemotactic receptor EBI2 in MS. Immune cells were isolated from patients and analyzed by flow cytometry and tested for migration in vitro. The data show that EBI2 is functionally expressed on memory T cells. These data suggest a significant role for EBI2 in T cell migration, notably in patients with MS. Further studies on EBI2 involvement in autoimmunity may lead to an improved understanding of MS physiopathology.
EBI2 expression and function: robust in memory lymphocytes and increased by natalizumab in multiple sclerosis
Caroline Pot
Added on: 10-19-2021
[1] https://www.cell.com/cell-reports/fulltext/S2211-1247(16)31679-5[2] https://data.jrc.ec.europa.eu/dataset/700397b2-edd7-4ed6-86f7-fc1b164ed432
