Plant extract to suppress metastatic cell behaviour
October 2018
School of Biosciences, Cardiff, United Kingdom
The hepatocyte growth factor can have pro-metastatic activity through the activation of the c-Met receptor. Recently, this signalling pathway has been described to be important in breast cancer progression and is linked to poor prognosis. Several studies have shown that plants from the genus Boswellia can have anti-cancer activity. Here, two triple-negative human breast cancer cell lines were used to study the effects of extracts of Boswellia frereana on several cancer- and metastasis-related features under stimulation of hepatocyte growth factor. The results showed that the hepatocyte growth factor induced an increase in several metastasis-related processes and c-Met activation in human cancer cells. However, there were no differences in the proliferation rate or spheroid formation of these cells. Upon treatment with the plant extract, the effect of hepatocyte growth factor was inhibited due to the extract-mediated inhibition of c-Met receptor tyrosine kinase phosphorylation. In this study, the researchers reveal a new potential drug candidate that suppresses the hepatocyte growth factor-mediated metastatic behaviour in human breast cancer cells.
Boswellia frereana suppresses HGF-mediated breast cancer cell invasion and migration through inhibition of c-Met signalling
Christian Parr
Added on: 10-18-2021
[1] https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-018-1660-y[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
