Nitrosamines in second-hand smoke can induce tumorigenicity
2018
Taipei Medical University, Taipei, Taiwan
Breast cancer is the most prevalent cancer in women worldwide. Despite the lack of solid confirmation, there is some evidence that suggests a direct correlation between the exposure of second-hand smoke and breast cancer risk. Here, a human immortalized non-tumorigenic breast cancer cell line was exposed to nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in time-course assays of 23 cycle-treatments to elucidate the carcinogenesis potential of these nitrosamines. The results showed that co-exposure of second-hand smoke doses of the nitrosamines induced changes in cell features associated with tumorigenicity. Additionally, there was an activation of factors associated with cellular proliferation and survival and cell stemness. Overall, the researchers demonstrate that chronic exposure to low doses of components of second-hand smoke can induce changes in cell physiology that could potentially drive towards tumorigenic behaviour.
Long-term exposure to extremely low-dose of nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induce non-malignant breast epithelial cell transformation through activation of the a9-nicotinic acetylcholine receptor-mediated
Yuan-Soon Ho
Added on: 10-13-2021
[1] https://onlinelibrary.wiley.com/doi/abs/10.1002/tox.22659[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
