Cancer promoting activity of cancer marker shown in vitro
2017
Soochow University, Jiangsu Changzhou, China(1)
University of Pittsburgh, Pittsburgh, USA(2)
University of Pittsburgh, Pittsburgh, USA(2)
PD-L1 is an immunomodulatory ligand that negatively regulates T cell activation, numerous studies have shown that many human cancers display PD-L1 over-expression which correlates with patients’ prognosis. Clinical studies have demonstrated that PD-L1 blockade can significantly inhibit tumor progression and improve patient prognosis. In the present study, the researchers aimed at understanding better the biological functions of PD-L1 in cancer cells. PD-L1 was shut on and off in oesophagal cancer cell lines to study its function and showed that PD-L1 expression significantly promoted the cell viability, migration and phenotypes associated with epithelial-to-mesenchymal transition (a hallmark of cancer). The present study reveals a tumor cell-autonomous role of PD-L1 signalling which strengthens its potential as treatment target.
PD-L1 expression promotes epithelial to mesenchymal transition in human esophageal cancer
Jingting Jiang(1), Binfeng Lu(2)
Added on: 09-14-2021
[1] https://www.karger.com/Article/Abstract/480000
