"ID";"Original Title";"Title";"Summary";"Contact";"Citation";"URL Scientific Article";"More References";"Keywords";"Field of Research";"Method/Model";"Year of Publication";"Month of Publication";"Date of Editing"; "904";"PD-L1 expression promotes epithelial to mesenchymal transition in human esophageal cancer";"Cancer promoting activity of cancer marker shown in vitro";"PD-L1 is an immunomodulatory ligand that negatively regulates T cell activation, numerous studies have shown that many human cancers display PD-L1 over-expression which correlates with patients’ prognosis. Clinical studies have demonstrated that PD-L1 blockade can significantly inhibit tumor progression and improve patient prognosis. In the present study, the researchers aimed at understanding better the biological functions of PD-L1 in cancer cells. PD-L1 was shut on and off in oesophagal cancer cell lines to study its function and showed that PD-L1 expression significantly promoted the cell viability, migration and phenotypes associated with epithelial-to-mesenchymal transition (a hallmark of cancer). The present study reveals a tumor cell-autonomous role of PD-L1 signalling which strengthens its potential as treatment target.";"Jingting Jiang, Soochow University, Jiangsu Changzhou, China, Binfeng Lu, University of Pittsburgh, Pittsburgh, USA";"Lujun Chen et al. Cellular Physiology and Biochemistry 2017";"https://www.karger.com/Article/Abstract/480000";"EURL ECVAM, https://data.jrc.ec.europa.eu/dataset/352f7dfd-05cf-434b-a96a-7e270dc76573";"T cells, immunotherapy, cancer therapy";"Gastroenterology, Hepatology, Haematology, Immunology, Molecular biology, Genetics, Oncology";"Cell culture, Tissue models";"2017";"08";"2021-09-14 17:25:51";