Non Animal Testing Database

Influence of toxic metals on neurodegenerative diseases

University of Belgrade - Faculty of Pharmacy, Belgrade, Serbia
The aim of this study was to investigate the influence of toxic metals present in the environment on the molecular mechanisms involved in the development of the neurodegenerative diseases (ND) amyotrophic lateral sclerosis (ALS), Parkinson’s Disease (PD) and Alzheimer’s disease (AD). Moreover, it investigated the capability of in silico toxicogenomic data-mining for distinguishing the probable mechanisms of mixture-induced toxic effects. The linkage between neurodegenerative diseases and toxic metals (Pb, MeHg (neurotoxic, organic form of mercury), Cd, As) was explored by analysing the chemical–gene/protein interactions obtained from the Comparative Toxicogenomics Database (CTD; The CTD data mining analysis revealed the genes connected to each of the investigated metals and linked to the development of the selected neurodegenerative diseases. SOD2 gene was noted as the mutual gene for all the selected ND. Oxidative stress, folate metabolism, vitamin B12, and apoptosis were noted as the key disrupted molecular pathways that contribute to the neurodegenerative disease’s development. The results emphasize the role of oxidative stress, particularly SOD2, in neurodegeneration triggered by environmental toxic metal mixture and give a new insight into common molecular mechanisms involved in ALS, PD and AD pathology.
Elucidating the influence of environmentally relevant toxic metal mixture on molecular mechanisms involved in the development of neurodegenerative diseases: In silico toxicogenomic data-mining
Danijela Đukić-Ćosić
Added on: 02-05-2024
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