Non Animal Testing Database

Analysis to predict diabetic kidney disease

The Chinese University of Hong Kong, Shatin, Hong Kong SAR of China
Epigenetic markers are potential biomarkers for diabetes and related complications. Using a prospective cohort from the Hong Kong Diabetes Register, the researchers performed two independent epigenome-wide association studies in 1,271 type 2 diabetes subjects. The identified 40 methylation markers associated with baseline estimated glomerular filtration rate and eight associated with subsequent decline in kidney function. They also developed a multisite analysis method, which selects CpG methylation sites as baseline for these pathologies. These models are validated in an independent cohort of Native Americans with type 2 diabetes. This study highlights the potential of methylation markers in risk stratification of kidney disease among type 2 diabetes individuals.
DNA methylation markers for kidney function and progression of diabetic kidney disease
Ronald C. W. Ma, Kevin Y. Yip
Added on: 06-05-2023
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