Analysis to predict diabetic kidney disease
2023
The Chinese University of Hong Kong, Shatin, Hong Kong SAR of China
Epigenetic markers are potential biomarkers for diabetes and related complications. Using a prospective cohort from the Hong Kong Diabetes Register, the researchers performed two independent epigenome-wide association studies in 1,271 type 2 diabetes subjects. The identified 40 methylation markers associated with baseline estimated glomerular filtration rate and eight associated with subsequent decline in kidney function. They also developed a multisite analysis method, which selects CpG methylation sites as baseline for these pathologies. These models are validated in an independent cohort of Native Americans with type 2 diabetes. This study highlights the potential of methylation markers in risk stratification of kidney disease among type 2 diabetes individuals.
DNA methylation markers for kidney function and progression of diabetic kidney disease
Ronald C. W. Ma, Kevin Y. Yip
Added on: 06-05-2023
[1] https://www.nature.com/articles/s41467-023-37837-7[2] https://www.drugtargetreview.com/news/110013/new-algorithm-can-predict-diabetic-kidney-disease/?utm_source=Email+marketing&utm_medium=email&utm_campaign=DTR+-+Newsletter+21+-+Revvity+-+01.06.2023&utm_term=Algae%3a+a+source+for+prebiotics+and+drugs+to+treat+IBD&utm_content=https%3a%2f%2femails.drugtargetreview.com%2frussellpublishinglz%2f&gator_td=qRVC2MyayzD2cFe1LNrZWtsWU0jpblON4wV1yBwnrT38WVXpicVs9xWfM710hpy2AmaoZBbGU47rvFGb%2bXB8%2bTsi4BIjf8fwXeSQ%2flz%2fHyyVOSBTukzxNz%2fEV85LqzLV%2fLFeK8Zip%2f60D9uo24Z4EYEyF2KgyW84OXnEraJWXtmS2EqjHodn3BFxdJmCHOcd44nx%2fJ21XybLL94jPCJcEiFx%2b2hjDoDKutGRRBzFnPo%3d
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