Non Animal Testing Database

Pan-cancer analysis of transposable elements

Washington University School of Medicine, St. Louis, USA
Cryptic promoters within transposable elements (TEs) can be transcriptionally reactivated in tumors to create new TE-chimeric transcripts, which can produce immunogenic antigens. The researchers performed a comprehensive screen for these TE exaptation events in 33 tumor types, 30 adult tissues and 675 cancer cell lines, and identified 1,068 TE-exapted candidates with the potential to generate shared tumor-specific TE-chimeric antigens (TS-TEAs). The authors highlight tumor-specific membrane proteins transcribed from TE promoters that constitute aberrant epitopes on the extracellular surface of cancer cells. Altogether, they showcase the high pan-cancer prevalence of TS-TEAs and atypical membrane proteins that could potentially be therapeutically exploited and targeted.
Pan-cancer analysis identifies tumor-specific antigens derived from transposable elements
Ting Wang
Added on: 05-02-2023
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