Pan-cancer analysis of transposable elements
2023
Washington University School of Medicine, St. Louis, USA
Cryptic promoters within transposable elements (TEs) can be transcriptionally reactivated in tumors to create new TE-chimeric transcripts, which can produce immunogenic antigens. The researchers performed a comprehensive screen for these TE exaptation events in 33 tumor types, 30 adult tissues and 675 cancer cell lines, and identified 1,068 TE-exapted candidates with the potential to generate shared tumor-specific TE-chimeric antigens (TS-TEAs). The authors highlight tumor-specific membrane proteins transcribed from TE promoters that constitute aberrant epitopes on the extracellular surface of cancer cells. Altogether, they showcase the high pan-cancer prevalence of TS-TEAs and atypical membrane proteins that could potentially be therapeutically exploited and targeted.
Pan-cancer analysis identifies tumor-specific antigens derived from transposable elements
Ting Wang
Added on: 05-02-2023
[1] https://www.nature.com/articles/s41588-023-01349-3[2] https://www.drugtargetreview.com/news/109123/analysis-of-33-tumour-types-identifies-new-immunotherapy-targets/?utm_source=Email+marketing&utm_medium=email&utm_campaign=DTR+-+Industry+Insight+-+Bio-Techne+-+Immuno-oncology+-+21.04.2023&utm_term=Major+lung+cancer+mechanism+can+be+used+to+evade+immune+attack&utm_content=https%3a%2f%2femails.drugtargetreview.com%2frussellpublishinglz%2f&gator_td=1eBvBtydZTk02FhRKAqSnkLwcvNVj%2fhiWD2OfnCgix%2bYMioj2Qv%2fS7NVESZ6TGRVHJMvxidAhmUAqmZm3n29RrbPuHB7vUvBPRff1eKtim05EI91O5K9ELcyuWRvD%2bsvV9xTb4RAjScokn9161ZB6xrUKzp8xxrO41SdoXoXP3ym1UullOiLRSXMLFPtewn%2bHU5U3h2gIrWRtOabpHD9viCGPXWpoSq8AkrcnLjJkLlAq%2bDvYBY9GSYJaNoJoeZ5opxb8YWHF%2bblTNQTpdKfbw%3d%3d
