Development of a vascularized tumor-on-chip model
2016
UC Irvine, Irvine, USA
The development of a tumor-on-chip 3D model to recapitulate solid tumor vascularization using human tumor and stromal cells growing in 3D extracellular matrices is presented. This model is able to support breast and colorectal cancer cells growth through living microvessels. Tumors growing in this platform show metabolic heterogeneity, with a preference for aerobic glycolysis. Finally, it is shown that with the use of different agents, it is possible to describe different mechanisms of vascular-targeting drugs, confirming that this can be an interesting model to study vascularized solid tumors and drug testing.
3D microtumors in vitro supported by perfused vascular networks
Christopher C W Hughes
Added on: 07-18-2021
[1] https://www.nature.com/articles/srep31589[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
