Non Animal Testing Database

Flower lose, a cell fitness marker, predicts COVID-19 prognosis

October 2021
Champalimaud Centre for the Unknown, Lisbon, Portugal(1)
University Hospital Basel and University of Basel, Basel, Switzerland(2)
A post-mortem examination of COVID-19 infected human lung tissues and an observational study were performed in order to evaluate whether expression of cell fitness marker hFwe-Lose in patient's nasopharyngeal swabs could predict hospitalization or death from COVID-19. In COVID-19 patients with acute lung injury, hFwe-Lose was highly expressed in the lower respiratory tract and was co-localised with areas of cell death. The hFwe-Lose expression in the patient's nasal swabs accurately predicted subsequent hospitalization or death due to COVID-19 infection. hFwe-Lose outperformed conventional inflammatory biomarkers and patient age and comorbidities in predicting hospitalization/death due to COVID-19 infection.
Flower lose, a cell fitness marker, predicts COVID-19 prognosis
Rajan Gogna(1), Eduardo Moreno(1), Alexandar Tzankov(2)
Added on: 05-12-2022
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