Modulation of hydrogels physiochemical cues to optimize tumor modelling
October 2017
University of Toronto, Toronto, Canada
The use of modulable hyaluronan hydrogels is analysed to better mimic the physiochemical properties of tumor microenvironments. After screening, the optimal hydrogel gives the best environment for human 3D breast cancer spheroids to reproduce their drug resistance mechanisms. Thus, these hydrogels can perform better than common Matrigel-based methods in drug screening assays.
Independently tuning the biochemical and mechanical properties of 3D hyaluronan-based hydrogels with oxime and Diels–Alder chemistry to culture breast cancer spheroids
Molly S Shoichet
Added on: 07-14-2021
[1] https://pubs.acs.org/doi/10.1021/acs.biomac.7b01422[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
