A multi-omics study of SARS-CoV-2 and SARS-CoV
2021
Technical University of Munich, Munich, Germany
The authors conducted a multi-omics study of SARS-CoV-2 and SARS-CoV. Using state-of-the-art proteomics, they profiled the interactome of both viruses, as well as their influence on transcriptome, proteome, ubiquitinome and phosphoproteome in a lung-derived human cell line. The extensive dataset (available at https://covinet.innatelab.org) highlights many hotspots that can be targeted by existing drugs and it can guide the rational design of virus- and host-directed therapies, which is exemplified by identifying kinase and matrix metalloproteases (MMPs) inhibitors with potent antiviral effects against SARS-CoV-2.
Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV
Andreas Pichlmair
Added on: 05-11-2021
[1] https://www.nature.com/articles/s41586-021-03493-4[2] https://www.bionity.com/en/news/1170704/a-multidimensional-view-of-the-coronavirus.html
