miR-155 can regulate cancer-related features in breast cancer cells
2018
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
Breast cancer remains one of the most prevalent and deadly cancers affecting women. In recent years, microRNAs have been identified as critical regulators in several types of cancers. Here, a human breast cancer cell line in different culture setups was used to investigate the miR-155-dependent modulation of proliferation and migration in breast cancer cells. The results showed that miR-155 mimics enhanced the expression of miR-155, whereas miR-155 inhibitors had the opposite effect. Furthermore, breast cancer cells transfected with miR-155 mimics had increased proliferation and migration, contrary to the decreased proliferation seen in the same cells treated with a miR-155 inhibitor. Finally, SOCS1 and MMP16 were identified as target proteins regulated by miR-155. Overall, the researchers confirm that miR-155 can influence breast cancer cell proliferation and migration via the modulation of target genes, which could make it a potential novel target for cancer therapy.
MiR-155 promotes the proliferation and migration of breast cancer cells via targeting SOCS1 and MMP16
Gui-Long Guo
Added on: 11-01-2021
[1] https://www.europeanreview.org/article/16269[2] https://data.jrc.ec.europa.eu/dataset/ffebe454-ed9a-47cf-8a33-8cf70c1b7d38
