Investigation of the role of natural killer cells in virus reactivation
2022
Hannover Medical School, Hanover, Germany
In this study, the immune responses of adaptive natural killer (NK) cells triggered by human cytomegalovirus (HCMV) reactivation were explored. Peripheral blood from HCMV-seropositive patients was collected after hematopoietic stem cell transplantation (HSCT) and analysed. Absolute cell counts of adaptive NK cells were determined and cytokine profiles were measured. Adaptive NK cells were expanded and their potential to eliminate HCMV-infected human fibroblasts as well as their ability to recruit T cells werestudied in vitro.
The study design allows for theinvestigation of the role of NK cells in the control of HCMV reactivation with regard to both, direct cytotoxicity and indirect effects by recruitment of other immune cells.
Adaptive NK cells undergo a dynamic modulation in response to human cytomegalovirus and recruit T cells in in vitro migration assays
Débora Basílio-Queirós
Added on: 08-23-2022
[1] https://www.nature.com/articles/s41409-022-01603-y
