"ID";"Original Title";"Title";"Summary";"Contact";"Citation";"URL Scientific Article";"More References";"Keywords";"Field of Research";"Method/Model";"Year of Publication";"Month of Publication";"Date of Editing"; "1795";"Multiplexed fluidic circuit board for controlled perfusion of 3D blood vessels-on-a-chip";"Controlled perfusion of 3D blood vessels-on-a-chip";"Three-dimensional (3D) blood vessels on a chip (VoC) models integrate the biological complexity of vessel walls with dynamic microenvironmental parameters such as wall shear stress (WSS) and circumferential strain (CS). However, these parameters are difficult to control and often poorly reproducible due to the high intrinsic diameter variations of individual 3D VoCs. As a result, the throughput of current 3D systems is limited to one channel. Here, a fluidic circuit board (FCB) was developed for simultaneous perfusion of up to twelve 3D VoCs with a single set of control parameters. By appropriately designing the internal hydraulic resistors in the FCB, it was possible to deliver a preset WSS to all connected 3D VoCs despite significant differences in lumen diameters. Using this FCB, variations in CS or WSS were found to induce morphological changes in human induced pluripotent stem cell (hiPSC)-derived endothelial cells (ECs), and the authors concluded that control of these parameters using an FCB is necessary for the study of 3D VoCs.";"Valeria V. Orlova, Leiden University Medical Center, Leiden, Netherlands";"Mees N. S. de Graaf et al. Lab on a Chip 2023";"https://pubs.rsc.org/en/content/articlelanding/2023/LC/D2LC00686C";"";"microfluidic device, blood vessels, 3D model";"Cardiology, Angiology, Method development";"Organ-on-a-chip, Microfluidics";"2022";"12";"2023-04-28 13:12:45";