"ID";"Original Title";"Title";"Summary";"Contact";"Citation";"URL Scientific Article";"More References";"Keywords";"Field of Research";"Method/Model";"Year of Publication";"Month of Publication";"Date of Editing"; "1787";"3D-printed long-acting 5-fluorouracil implant to prevent conjunctival fibrosis in glaucoma";"3D-printed implant to prevent conjunctival fibrosis in glaucoma";"After glaucoma surgery, conjunctival fibrosis is common. Multiple injections of the substance 5-fluorouracil (5-FU) under the conjunctiva should prevent this, but this treatment has some disadvantages. This study focuses on the development of a delayed-release 5-FU implant using 3D bioprinting. For this purpose, the implant made of polycaprolactone (PCL) and chitosan (CS) was loaded with 1% 5-FU. The 5-FU concentration released over 8 weeks was measured by ultraviolet visible spectroscopy. The effects on cell viability, fibroblast contractility, and expression of major fibrotic genes were studied in human conjunctival fibroblasts. The PCL-CS-5-FU implant released 5-FU for 8 weeks, during which time conjunctival fibroblast viability was unaffected, but fibroblast contractility and major fibrotic genes were persistently suppressed. The results suggest that the PCL-CS-5-FU implant can be used as a sustained-release implant to replace repeated 5-FU injections after glaucoma surgery.";"Cynthia Yu-Wai-Man, King’s College London, London, United Kingdom";"Nicole Ioannou et al. Journal of Pharmacy and Pharmacology 2023";"https://academic.oup.com/jpp/article/75/2/276/6972810";"";"drug development, fibrosis, glaucoma, conjunctiva";"Drug development and testing, Medical devices, Implants, Method development, Ophthalmology";"3D bioprinting, Cell culture, Tissue models";"2023";"01";"2023-04-25 13:40:46";