"ID";"Original Title";"Title";"Summary";"Contact";"Citation";"URL Scientific Article";"More References";"Keywords";"Field of Research";"Method/Model";"Year of Publication";"Month of Publication";"Date of Editing"; "1583";"Biomimetic keratin-coated gold nanoparticles for photo-thermal therapy in a 3D bioprinted glioblastoma tumor model";"Photo-thermal therapy in a 3D bioprinted glioblastoma model";"Photo-thermal therapy (PTT) is a minimally invasive cancer treatment that relies on the capability of photosensitizing agents to generate highly localized thermal heating for the selective thermal ablation of tumors. This study reports on a powerful combination of 3D bioprinting (3DB) and PTT applications. To this end, the researchers realize a 3DB construct consisting of glioblastoma U87-MG cells in a 3D geometry, incorporating biomimetic keratin-coated gold nanoparticles (Ker-AuNPs) as a photo-thermal agent. The resulting plasmonic 3DB structures exhibit a homogeneous cell distribution throughout the entire volume while promoting the localization of Ker-AuNPs within the cells. Laser-assisted PTT experiments demonstrate the extraordinary ability of Ker-AuNPs to generate heating, producing the highest temperature rise of about 16 °C in less than 2 min.";"Luciano De Sio, Sapienza University of Rome, Latina, Italy";"Maila Chirivì et al. International Journal of Molecular Sciences 2022";"https://www.mdpi.com/1422-0067/23/17/9528/htm";"";"glioblastoma, cancer therapy, brain tumor";"Drug development and testing, Method development, Neurology, Oncology";"3D bioprinting";"2022";"08";"2022-10-25 17:10:33";