"ID";"Original Title";"Title";"Summary";"Contact";"Citation";"URL Scientific Article";"More References";"Keywords";"Field of Research";"Method/Model";"Year of Publication";"Month of Publication";"Date of Editing"; "1448";"Establishing an air-liquid interface exposure system for exposure of lung cells to gases";"Air-liquid interface exposure";"An air-liquid interface (ALI) exposure system for reproducible exposure of cells to gases was developed in this study. Optimization of the exposure conditions (temperature, humidity and airflow) resulted in stable and reproducible delivery and reliable monitoring of the test atmospheres for human lung cancer (A549) cells at the ALI. Toxicologically-relevant biological responses were assessed during exposure of cells to air or ozone. The described optimization process is critical to ensure that toxicity can be attributed to the action of the test agent, rather than to suboptimal exposure conditions. This facilitates the development of advanced in vitro-based approaches for inhalation toxicology.";"Errol Thomson, Environmental Health Science and Research Bureau, Ottawa, Canada";"Josée Guénette et al. Inhalation Toxicology 2022";"https://www.tandfonline.com/doi/full/10.1080/08958378.2022.2039332";"";"toxicity, air-liquid-interface, inhalation exposure systems, airways";"Drug development and testing, Method development, Pneumology, Toxicology";"Cell culture, Tissue models, Organ-on-a-chip, Microfluidics";"2022";"02";"2022-05-27 10:06:06";