"ID";"Original Title";"Title";"Summary";"Contact";"Citation";"URL Scientific Article";"More References";"Keywords";"Field of Research";"Method/Model";"Year of Publication";"Month of Publication";"Date of Editing"; "1446";"Multi-compartment lymph-node-on-a-chip enables measurement of immune cell motility in response to drugs";"Lymph node on-a-chip to study cell dynamics and drug interactions";"Lymph nodes (LN) are crucial locations where an immune response is intiated, yet it is difficult to replicate their structure and function in vitro. Here, a LN on-a-chip is constructed that resembles a human LN closely. The extracellular matrix (ECM) composition is comparabel, as well as its morphology, porosity, stiffness, and permeability. The immune cells reside in different compartments like in the human LN and a lymph fluid that flows through the device is diverted to a web like systems in a smilar flow pattern. The cells encapsulated in the hydrogel show typical viability and interaction among the cell types across chamber barriers can be observed. To test the device, hydroxychloroquine is used to investigate cell dynamics to this drug. The results suggest that the LN on-a-chip is a suitable 3D tool to study cellular dynamics, complex biological processes and drug-cell interactions.";"Lourdes Planelles, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates, Cesare Stefanini, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates";"Nicholas Hallfors et al. Bioengineering 2021";"www.mdpi.com/2306-5354/8/2/19";"";"extracellular matrix, immune system, immune response, drug delivery, drug development, drug interaction, drug testing, lymphatic system";"Haematology, Immunology, Drug development and testing, Method development";"Organ-on-a-chip, Microfluidics";"2021";"01";"2022-05-17 16:49:33";