"ID";"Original Title";"Title";"Summary";"Contact";"Citation";"URL Scientific Article";"More References";"Keywords";"Field of Research";"Method/Model";"Year of Publication";"Month of Publication";"Date of Editing"; "1310";"Modeling human adaptive immune responses with tonsil organoids";"Tonsil organoids elucidate adaptive immune responses";"Currently, most of the studies on adaptive immunity have been done on mouse models with limited translationality. Moreover, vaccine assays in mice are usually poorly predictive of their outcome in humans. Here, human tonsils are used to develop physiological and functionally relevant organotypic cultures that recapitulate in vitro key germinal characteristics to perform immunity assays. The results elucidated the critical cellular components to induce an immune response to an influenza vaccine. Furthermore, it was also possible to trigger humoral immunity when testing vaccines against SARS-CoV-2 or rabies and using different adjuvants. Overall, the researchers develop an in vitro system that allows to rapidly test vaccines and adjuvants in a human system and evaluate the adaptive immune response and the mechanisms underlying it.";"Mark M Davis, Stanford University, Stanford, USA";"Lisa E Wagar et al. Nature Medicine 2021";"https://www.nature.com/articles/s41591-020-01145-0";"";"SARS-CoV-2, immune system, adaptive immunity, vaccines, immunity, immune response, influenza, organotypic cultures";"Haematology, Immunology, Drug development and testing, Method development, Microbiology, Infectiology";"Cell culture, Tissue models, Organoids, Spheroids, (Bio-)Assays";"2021";"01";"2021-12-02 18:40:41";