A functional map of HIV-host interactions in primary human T cells
2022
Northwestern University Feinberg School of Medicine, Chicago, USA(1)
University of California, San Francisco, USA(2)
University of California, San Francisco, USA(2)
In the study, T cells, the major cell type targeted by HIV, were isolated from donated human blood and hundreds of genes were knocked out using CRISPR-Cas9 gene editing. The “knock-out” cells were then infected with HIV and analysed. The researchers found 86 genes that may play a role in the way HIV replicates and causes disease, including over 40 that have never been looked at in the context of HIV infection. The study highlights a new way of understanding how HIV integrates into our DNA and establishes a chronic infection, leading towards new treatments.
A functional map of HIV-host interactions in primary human T cells
Judd F. Hultquist(1), Alexander Marson(2), Nevan J. Krogan(2)
Added on: 06-09-2022
[1] https://www.nature.com/articles/s41467-022-29346-w[2] https://www.drugtargetreview.com/news/102434/new-crispr-could-lead-to-better-treatments-for-hiv/?utm_source=Email+marketing&utm_medium=email&utm_campaign=DTR+-+Industry+Insight+-+Bio-Rad+-+Cell+and+Gene+Therapy+-+13.05.22&utm_term=Cell-derived+therapy+may+help+repair+abnormal+heart+rhythm&utm_content=https%3a%2f%2femails.drugtargetreview.com%2frussellpublishinglz%2f&gator_td=YBGLCJOd3GYOJik4M8QTppp6xJiaE7Sv27AHNhoJjBsH1%2bA8iMHHRKbETShrUBXL5x7VeBOy%2bpNEwIDZtvIjt8kQcUeEfeWPhYB3eQCdifACOYmCMt7BAj0v%2bdj0TdRv9CTLmvW64%2fDo7TvYyD1io5EvbuFEZ388bPsy60AYqguryqDaz4m6t6RV79ivVf%2bheSc1BDLR8l6K6XTXR80qFHKoCEhv2MrRO7RcsV2xVPhz%2bdwIsdg39Nmd9GYMjOI3EC%2f6GIypeEkzn3qtg630ZA%3d%3d
